|The SARNP sarnp (Catalog #MBS9221738) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The SARNP sarnp product has the following accession number(s) (GI #18202440) (NCBI Accession #P82979.3) (Uniprot Accession #P82979). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Cellular Location: Nucleus. Nucleus speckle. Tissue Location: Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma. The following patways have been known to be associated with this gene. Brain, Embryonic Tissue, Liver, Lung tissues are correlated with this protein. Brain Diseases, Carcinoma, Squamous Cell, Chromosome Aberrations, Fatty Liver, Liver Diseases, Liver Neoplasms are some of the diseases may be linked to SARNP Antibody (Center) Blocking Peptide.