|The RYK ryk (Catalog #MBS9227156) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The RYK ryk product has the following accession number(s) (GI #1710811) (NCBI Accession #P34925.2) (Uniprot Accession #P34925). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
Cellular Location: Membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note: In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. Tissue Location: Observed in all the tissues examined. The following patways have been known to be associated with this gene. Bladder, Blood, Bone, Brain, Embryonic Tissue, Heart, Kidney, Lung, Nerve, Vascular tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Hepatocellular, Craniofacial Abnormalities, Disease Models, Animal, Glioblastoma, Inflammation, Kidney Diseases, Nervous System Diseases, Proteinuria are some of the diseases may be linked to RYK Antibody Blocking Peptide.