|The ROS1 ros1 (Catalog #MBS9229514) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The ROS1 ros1 product has the following accession number(s) (GI #126302596) (NCBI Accession #P08922.3) (Uniprot Accession #P08922). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: Expressed in brain. Expression is increased in primary gliomas. ROS1 also interacts with the following gene(s): ABL1, EGFR, OR13G1, PALLD, TAS2R50. Brain, Liver, Lung, Vascular tissues are correlated with this protein. Adenocarcinoma of lung, Breast Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Glioma, Infertility, Male, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Experimental are some of the diseases may be linked to ROS1 Blocking Peptide (C-term).