RNF43 blocking peptide product blog
Tags: Blocking Peptide; RNF43; RNF43 blocking peptide;
The RNF43 rnf43 (Catalog #MBS9219746) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The RNF43 rnf43 product has the following accession number(s) (GI #74757361) (NCBI Accession #Q68DV7.1) (Uniprot Accession #Q68DV7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note: According to a report, may be secreted. Tissue Location: Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines. The following patways have been known to be associated with this gene. RNF43 also interacts with the following gene(s): AKAP8L, HECW1, LGR5, NONO, RSPO1, SFPQ, TP53. Blood, Brain, Embryonic Tissue, Intestine, Liver, Lung, Ovary, Pancreas, Stomach, Testis tissues are correlated with this protein. Cholangiocarcinoma, Colorectal Neoplasms, Endometrial Neoplasms, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental, Pancreatic Neoplasms, Precancerous Conditions, Stomach Neoplasms are some of the diseases may be linked to RNF43 Antibody (C-term) Blocking Peptide.