|The RNF34 (HGNC:17297) rnf34 (Catalog #MBS9221868) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The RNF34 (HGNC:17297) rnf34 product has the following accession number(s) (GI #74760679) (NCBI Accession #Q969K3.1) (Uniprot Accession #Q969K3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate \'Lys-48\'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through \'Lys-48\'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).
Cellular Location: Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Nucleus. Nucleus speckle. Cytoplasm, cytosol. Tissue Location: Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes. Blood, Brain, Heart, Liver, Lymph Node, Muscle, Nerve, Ovary, Stomach, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Carcinoma, Colonic Neoplasms, Disease Models, Animal, Inflammation, Learning Disorders, Liver Neoplasms, Memory Disorders, Necrosis, Neoplasm Metastasis, Nervous System Diseases are some of the diseases may be linked to RNF34 Antibody (C-term) Blocking Peptide.