|The RNF31 rnf31 (Catalog #MBS9224180) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The RNF31 rnf31 product has the following accession number(s) (GI #45477216) (NCBI Accession #Q96EP0.1) (Uniprot Accession #Q96EP0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (\'Met-1\'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF- induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
Cellular Location: Cytoplasm. Tissue Location: Expressed in both normal and transformed breast epithelial cell lines. Adrenal Gland, Blood, Embryonic Tissue, Lung, Nerve, Prostate, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene. RNF31 also interacts with the following gene(s): BIRC2, FAM105B, IKBKG, RBCK1, SHARPIN, TRAF2, VCP. Carcinoma, Immune System Diseases, Inflammation, Lymphoma, Necrosis, Ovarian Diseases, Ovarian Neoplasms are some of the diseases may be linked to RNF31 Antibody (C-term) Blocking Peptide.