Rnasel blocking peptide product blog
Tags: Blocking Peptide; RNASEL; Rnasel blocking peptide;
The Rnasel rnasel (Catalog #MBS9222577) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Rnasel rnasel product has the following accession number(s) (GI #20141791) (NCBI Accession #Q05921.2) (Uniprot Accession #Q05921). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity).
Cellular Location: Cytoplasm. Mitochondrion. Tissue Location: Expressed in spleen, thymus, lung, testis, kidney, liver and heart. Disease Models, Animal, Hyperplasia, Inflammation, Liver Diseases, Lung Neoplasms, Necrosis, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases, Prostatic Neoplasms are some of the diseases may be linked to Mouse Rnasel Antibody (N-term) Blocking Peptide. Bladder, Blood, Bone Marrow, Brain, Embryonic Tissue, Kidney, Lung, Lymph Node, Muscle, Skin tissues are correlated with this protein. Rnasel also interacts with the following gene(s): Ifih1, Isg15, Stat1. The following patways have been known to be associated with this gene.