RIPK3 positive control product blog
Tags: Ripk3; Positive Control; RIPK3 positive control;
The RIPK3 ripk3 (Catalog #MBS543200) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s RIPK3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western Blot: 1:500. Researchers should empirically determine the suitability of the RIPK3 ripk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The RIPK3 ripk3 product has the following accession number(s) (GI #40254844) (NCBI Accession #NP_006862.2) (Uniprot Accession #Q9Y572). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Western Blot Positive Control Receptor-interacting Serine/Threonine-protein kinase 3 Antibody C-epitope
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL.
Immunogen: Purified Protein
Expression: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. Determinant: C-epitope
Molecular Function: Kinase, Serine/threonine-protein kinase, Transferase
Structure: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
Subcellular Location: Cytoplasm, Cell membrane, Mitochondrion. The following patways have been known to be associated with this gene. RIPK3 also interacts with the following gene(s): CASP8, FADD, MLKL, RIPK1, TICAM1, TLR3, ZBP1. Blood, Brain, Heart, Intestine, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. Acute Kidney Injury, Cardiovascular Diseases, Drug-Induced Liver Injury, Drug-Related Side Effects and Adverse Reactions, Heart Diseases, Hypertension, Inflammation, Liver Diseases, Necrosis, Vascular Diseases are some of the diseases may be linked to RIPK3 Antibody Western Blot Positive Control.