RBX1 blocking peptide product blog
Tags: Blocking Peptide; Rbx1; RBX1 blocking peptide;
The RBX1 rbx1 (Catalog #MBS9229209) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The RBX1 rbx1 product has the following accession number(s) (GI #51338609) (NCBI Accession #P62877.1) (Uniprot Accession #P62877). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41. In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM.
Cellular Location: Cytoplasm. Nucleus. Tissue Location: Widely expressed. Adenocarcinoma, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Inflammation, Kidney Diseases, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to RBX1 Blocking Peptide (C-term). Blood, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. RBX1 also interacts with the following gene(s): CDC34, CUL1, CUL2, CUL3, CUL4A, CUL5, SKP1, UBE2D1, UBE2D2, UBE2M.