|The RBL1 rbl1 (Catalog #MBS9225059) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The RBL1 rbl1 product has the following accession number(s) (GI #90103515) (NCBI Accession #P28749.3) (Uniprot Accession #P28749). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Cellular Location: Nucleus. RBL1 also interacts with the following gene(s): CDK2, CDK4, E2F1, E2F2, E2F3, E2F4, E2F5, MYBL2, TFDP1, TFDP2. The following patways have been known to be associated with this gene. Disease Models, Animal, Hyperplasia, Liver Diseases, Liver Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases, Precancerous Conditions are some of the diseases may be linked to Phospho-Rb-like-1(S975) Antibody Blocking peptide. Blood, Brain, Embryonic Tissue, Eye, Heart, Liver, Lung, Prostate, Skin, Uterus tissues are correlated with this protein.