RB1 blocking peptide product blog
Tags: RB1; Blocking Peptide; RB1 blocking peptide; RB1 (S608);
The RB1 rb1 (Catalog #MBS9225996) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The RB1 rb1 product has the following accession number(s) (GI #132164) (NCBI Accession #P06400.2) (Uniprot Accession #P06400). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1\'s activity.
Cellular Location: Nucleus. Tissue Location: Expressed in the retina. RB1 also interacts with the following gene(s): CCND1, CCNE1, CDK2, CDK4, CDK6, E2F1, E2F2, E2F3, TFDP2. Blood, Bone, Brain, Eye, Intestine, Liver, Lung, Muscle, Prostate, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Carcinoma, Liver Diseases, Lung Neoplasms, Necrosis, Neoplasms, Experimental, Osteosarcoma, Retinoblastoma, Small Cell Lung Carcinoma are some of the diseases may be linked to RB1 Antibody (S608) Blocking Peptide.