RAD9A blocking peptide product blog
Tags: Blocking Peptide; RAD9A; RAD9A blocking peptide; RAD9 (Y28);
The RAD9A rad9a (Catalog #MBS9225058) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The RAD9A rad9a product has the following accession number(s) (GI #74717382) (NCBI Accession #Q99638.1) (Uniprot Accession #Q99638). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3\'->5\' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
Cellular Location: Nucleus. Embryonic Tissue, Intestine, Lung, Skin, Testis tissues are correlated with this protein. Breast Neoplasms, Lung Neoplasms, Neoplasms, Experimental, Neoplasms, Second Primary, Skin Neoplasms are some of the diseases may be linked to Phospho-RAD9(Y28) Antibody Blocking peptide. The following patways have been known to be associated with this gene.