RAD17 blocking peptide product blog
Tags: Blocking Peptide; RAD17; RAD17 blocking peptide;
The RAD17 rad17 (Catalog #MBS9218572) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The RAD17 rad17 product has the following accession number(s) (GI #62287484) (NCBI Accession #O75943.2) (Uniprot Accession #O75943). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Cellular Location: Nucleus. Note: Phosphorylated form redistributes to discrete nuclear foci upon DNA damage. Tissue Location: Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors). Anemia, Breast Neoplasms, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Disease Models, Animal, Liver Diseases, Liver Neoplasms, Micronuclei, Chromosome-Defective, Necrosis, Nervous System Diseases are some of the diseases may be linked to RAD17 Antibody (Center) Blocking peptide. The following patways have been known to be associated with this gene. RAD17 also interacts with the following gene(s): ATM, ATR, CLSPN, HUS1, MCM7, RAD1, RAD9A, RFC3, RFC4, RFC5. Blood, Brain, Intestine, Lung, Lymph Node, Muscle, Prostate, Testis, Thymus, Uterus tissues are correlated with this protein.