Pxn peptide product blog
Tags: Peptide; PXN; Paxillin (C-terminal) Peptide; Pxn peptide;
The Pxn pxn (Catalog #MBS474018) is a Peptide and is intended for research purposes only. The product is available for immediate purchase.Antibody Blocking: 1 ug/ml
ELISA: 10-100 ng/well. Researchers should empirically determine the suitability of the Pxn pxn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Pxn pxn product has the following accession number(s) (GI #58865866) (NCBI Accession #NP_001012147.1) (Uniprot Accession #Q66H76). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Peptide Sequence: A synthetic peptide correspond ing to amino acid residues in the C-terminal region of human Paxillin. This peptide sequence is highly conserved in rat and mouse paxillin, and is found in all three paxillin isoforms (alpha, beta, and gamma).
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of proteinprotein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Serine phosphorylation of paxillin occurs in response to growthfactor activation and fibronectins. Both JNK1 and cdc2 kinases can phosphorylate serine 178 in paxillin. The mutant form of paxillin (S178A) decreases the migration of keratocytes and epithelial cells. Thus, phosphorylation paxillin at serine 178 may be important during cell migration.
The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Cell Transformation, Neoplastic, Inflammation, Leukemia, Lung Diseases, Necrosis, Neoplasm Metastasis, Neoplasms, Neoplasms, Experimental are some of the diseases may be linked to Paxillin (C-terminal) Blocking Peptide. Pxn also interacts with the following gene(s): Ilk. Brain, Colon, Embryonic Tissue, Eye, Heart, Kidney, Lung, Muscle, Placenta, Prostate tissues are correlated with this protein.