PUF60 blocking peptide product blog
Tags: Blocking Peptide; PUF60; PUF60 blocking peptide;
The PUF60 puf60 (Catalog #MBS9220723) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The PUF60 puf60 product has the following accession number(s) (GI #74761960) (NCBI Accession #Q9UHX1.1) (Uniprot Accession #Q9UHX1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3\'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3\'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.
Cellular Location: Nucleus. Note: Colocalizes partially with TROVE2. Tissue Location: Isoform 2 is expressed in colonic epithelium and colorectal epithelium cancer (at protein level). Isoform 6 is expressed in colorectal epithelial cancer but below detection level in colonic epithelium. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. The following patways have been known to be associated with this gene. Inflammation, Neoplasm Metastasis, Ovarian Diseases, Ovarian Neoplasms are some of the diseases may be linked to PUF60 Antibody (N-term) Blocking Peptide. Blood, Heart, Intestine, Lymph, Lymph Node, Muscle, Ovary, Skin, Stomach tissues are correlated with this protein.