PTPN11 blocking peptide product blog
Tags: PTPN11; Blocking Peptide; PTPN11 blocking peptide; SHP2 (Y584);
The PTPN11 ptpn11 (Catalog #MBS9225237) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The PTPN11 ptpn11 product has the following accession number(s) (GI #84028248) (NCBI Accession #Q06124.2) (Uniprot Accession #Q06124). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Cellular Location: Cytoplasm. Tissue Location: Widely expressed, with highest levels in heart, brain, and skeletal muscle. Blood, Bone, Bone Marrow, Brain, Heart, Liver, Muscle, Nerve, Skin, Stomach tissues are correlated with this protein. The following patways have been known to be associated with this gene. PTPN11 also interacts with the following gene(s): EGFR, FRS2, GAB1, GAB2, GRB2, IRS1, JAK1, JAK2, PDGFRB, PXN. Adenocarcinoma, Carcinoma, Costello Syndrome, Heart Diseases, Inflammation, LEOPARD Syndrome, Leukemia, Leukemia, Myelomonocytic, Juvenile, Necrosis, Noonan Syndrome are some of the diseases may be linked to Phospho-SHP2(Y584) Antibody Blocking peptide.