|The PTH pth (Catalog #MBS634023) is a Peptide produced from Synthetic peptide and is intended for research purposes only. The product is available for immediate purchase. The Parathyroid Hormone [Tyr27] (PTH) (27-48) (human) reacts with Human and may cross-react with other species as described in the data sheet.
The PTH pth product has the following accession number(s) (GI #4506267) (NCBI Accession #NP_000306.1) (Uniprot Accession #P01270). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Polypeptide hormones secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. Its action is opposed by calcitonin. Parathyroid hormone (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptor in three parts of the body. PTH half-life is approximately 4 minutes. PTH enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Stimulation is indirect since osteoclasts do not have a receptor for PTH; rather, PTH binds to osteoblasts, the cells responsible for creating bone. Binding stimulates osteoblasts to increase their expression of RANKL, which can bind to osteoclast precursors containing RANK, a receptor for RANKL. The binding of RANKL to RANK stimulates these precursors to fuse, forming new osteoclasts which ultimately enhances the resorption of bone.
Sequence (linear): Tyr-Leu-Gln-Asp-Val-His-Asn-Phe-Val-Ala-Leu-Gly-Ala-Pro-Leu-Ala-Pro-Arg-Asp-Ala-Gly-Ser. PTH also interacts with the following gene(s): CALCA, CASR, FGF23, GCG, PTH1R, PTH2R, PTHLH, VDR. The following patways have been known to be associated with this gene. Bone Diseases, Bone Diseases, Metabolic, Bone Resorption, Hypercalcemia, Hyperparathyroidism, Hyperparathyroidism, Secondary, Kidney Diseases, Kidney Failure, Chronic, Osteoporosis, Renal Insufficiency are some of the diseases may be linked to Parathyroid Hormone [Tyr27] (PTH) (27-48) (human). Connective Tissue, Embryonic Tissue, Parathyroid tissues are correlated with this protein.