|The PTGDS ptgds (Catalog #MBS9229714) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The PTGDS ptgds product has the following accession number(s) (GI #730305) (NCBI Accession #P41222.1) (Uniprot Accession #P41222). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
Cellular Location: Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note: Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted. Tissue Location: Abundant in the brain and CNS, where it is expressed in tissues of the blood-brain barrier and secreted into the cerebro-spinal fluid. Abundantly expressed in the heart. In the male reproductive system, it is expressed in the testis, epididymis and prostate, and is secreted into the seminal fluid Expressed in the eye and secreted into the aqueous humor. Lower levels detected in various tissue fluids such as serum, normal urine, ascitic fluid and tear fluid. Also found in a number of other organs including ovary, fimbriae of the fallopian tubes, kidney, leukocytes. PTGDS also interacts with the following gene(s): HPGDS, PTGES, PTGES2, PTGES3, PTGIS, PTGS1, PTGS2, TBXAS1. The following patways have been known to be associated with this gene. Atherosclerosis, Cardiovascular Diseases, Depressive Disorder, Disease Models, Animal, Heart Diseases, Hypertension, Inflammation, Kidney Diseases, Neoplasms, Experimental, Pain are some of the diseases may be linked to PTGDS Blocking Peptide (C-term). Adipose Tissue, Blood, Brain, Connective Tissue, Eye, Kidney, Nerve, Ovary, Prostate, Testis tissues are correlated with this protein.