PRUNE blocking peptide product blog
Tags: Blocking Peptide; PRUNE; PRUNE blocking peptide;
The PRUNE prune (Catalog #MBS9228378) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The PRUNE prune product has the following accession number(s) (GI #229462737) (NCBI Accession #Q86TP1.2) (Uniprot Accession #Q86TP1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
Cellular Location: Cytoplasm. Nucleus. Cell junction, focal adhesion. Note: In some transfected cells a nuclear staining is also observed. Tissue Location: Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. The following patways have been known to be associated with this gene.