|The PRICKLE1 prickle1 (Catalog #MBS9223825) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The PRICKLE1 prickle1 product has the following accession number(s) (GI #59800163) (NCBI Accession #Q96MT3.2) (Uniprot Accession #Q96MT3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
Cellular Location: Nucleus membrane. Cytoplasm, cytosol. Note: A smaller amount is detected in the cytosol. Tissue Location: Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia). PRICKLE1 also interacts with the following gene(s): DVL1, DVL2, DVL3, SMURF1, UBC, VANGL1, VANGL2. Brain Diseases, Carcinoma, Hepatocellular, Chromosome Aberrations, Congenital Abnormalities, Disease Models, Animal, Kidney Diseases, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Proteinuria are some of the diseases may be linked to PRICKLE1 Antibody (C-term) Blocking Peptide. Brain tissues are correlated with this protein. The following patways have been known to be associated with this gene.