|The Pkmyt1 pkmyt1 (Catalog #MBS9220441) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The Pkmyt1 pkmyt1 product has the following accession number(s) (GI #341942188) (NCBI Accession #Q9ESG9.3) (Uniprot Accession #Q9ESG9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on \'Thr-14\'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on \'Tyr-15\' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development (By similarity).
Cellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Brain, Liver tissues are correlated with this protein. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Hepatocellular, Kidney Diseases, Kidney Neoplasms, Liver Diseases, Liver Neoplasms, Necrosis, Neoplasm Invasiveness, Neoplasm Metastasis are some of the diseases may be linked to Mouse Pkmyt1 Antibody (N-term) Blocking peptide.