|The PKM pkm (Catalog #MBS9226646) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The PKM pkm product has the following accession number(s) (GI #20178296) (NCBI Accession #P14618.4) (Uniprot Accession #P14618). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Cellular Location: Cytoplasm. Nucleus. Note: Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity. Tissue Location: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. The following patways have been known to be associated with this gene. Blood, Brain, Heart, Kidney, Liver, Lung, Muscle, Nerve, Thyroid, Vascular tissues are correlated with this protein. Carcinoma, Cardiovascular Diseases, Cell Transformation, Neoplastic, Disease Models, Animal, Fibrosis, Inflammation, Liver Diseases, Lung Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to PKM2 Antibody (C-term L398) Blocking Peptide. PKM also interacts with the following gene(s): ALDOA, ENO1, ENO2, GPI, HIF1A, LDHB, PGK1.