PIM2 blocking peptide product blog
Tags: Blocking Peptide; PIM2; PIM2 blocking peptide;
The PIM2 pim2 (Catalog #MBS9227391) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The PIM2 pim2 product has the following accession number(s) (GI #20139243) (NCBI Accession #Q9P1W9.1) (Uniprot Accession #Q9P1W9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti- apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Tissue Location: Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues. Blood, Bone, Bone Marrow, Heart, Liver, Lung, Lymph Node, Prostate, Spleen, Thymus tissues are correlated with this protein. Adenocarcinoma, Carcinoma, Hepatocellular, Heart Diseases, Inflammation, Leukemia, Myeloid, Acute, Liver Diseases, Liver Neoplasms, Necrosis, Neoplasms, Experimental, Prostatic Neoplasms are some of the diseases may be linked to PIM2 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene. PIM2 also interacts with the following gene(s): API5, CDKN1A, EIF4EBP1, FOXP3, IL3, SOCS1, SOCS3, TNFSF13B.