|The PIKFYVE pikfyve (Catalog #MBS9226643) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The PIKFYVE pikfyve product has the following accession number(s) (GI #300669693) (NCBI Accession #Q9Y2I7.3) (Uniprot Accession #Q9Y2I7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
Cellular Location: Endosome membrane Note: Mainly associated with membranes of the late endocytic pathway. The following patways have been known to be associated with this gene. PIKFYVE also interacts with the following gene(s): AKT1, FIG4, MTMR2, PIK3C3, SGK1, SGK3, VAC14. Body Weight Changes, Congenital Abnormalities, Corneal Dystrophy, Fleck, Fibrosis, Glucose Intolerance, Heart Defects, Congenital, Inflammation, Kidney Diseases, Nerve Degeneration, Peripheral Nervous System Diseases are some of the diseases may be linked to PIP5K3 Antibody (Center) Blocking Peptide. Blood, Brain, Embryonic Tissue, Eye, Intestine, Kidney, Liver, Muscle, Ovary, Thymus tissues are correlated with this protein.