PIAS2 blocking peptide product blog
Tags: PIAS2; Blocking Peptide; PIAS2 blocking peptide; PIAS2 (PIASx1);
The PIAS2 pias2 (Catalog #MBS9219173) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The PIAS2 pias2 product has the following accession number(s) (GI #229463031) (NCBI Accession #O75928.3) (Uniprot Accession #O75928). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2- alpha. Isoform PIAS2-alpha sumoylates PML at\'Lys-65\' and \'Lys- 160\'.
Cellular Location: Nucleus speckle. Nucleus, PML body. Note: Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs). Tissue Location: Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs. The following patways have been known to be associated with this gene. Brain Diseases, Chromosome Aberrations, Congenital Abnormalities, Fibrosis, Genital Diseases, Male, Immune System Diseases, Inflammation, Nerve Degeneration, Nervous System Diseases are some of the diseases may be linked to PIAS2 (PIASx1) Antibody (C-term) Blocking peptide. Bone, Brain, Embryonic Tissue, Liver, Muscle, Pancreas, Testis, Thymus, Thyroid tissues are correlated with this protein.