|The PGR pgr (Catalog #MBS9224158) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The PGR pgr product has the following accession number(s) (GI #90110048) (NCBI Accession #P06401.4) (Uniprot Accession #P06401). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Cellular Location: Nucleus. Cytoplasm. Note: Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases Isoform 4: Mitochondrion outer membrane. Adenocarcinoma, Breast Neoplasms, Carcinoma, Endometrial Neoplasms, Hyperplasia, Liver Neoplasms, Mammary Neoplasms, Animal, Mammary Neoplasms, Experimental, Neoplasms, Experimental, Recurrence are some of the diseases may be linked to PGR/PR Antibody (C-term) Blocking Peptide. PGR also interacts with the following gene(s): BRCA1, CCND1, ERBB2, ESR1, MAPK1, NCOA1, NCOA3, SP1, SRC. The following patways have been known to be associated with this gene. Brain, Cervix, Lung, Mammary Gland, Muscle, Ovary, Prostate, Stomach, Uterus, Vascular tissues are correlated with this protein.