|The PDE5A pde5a (Catalog #MBS544216) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s PDE5A can be used in a range of immunoassay formats including, but not limited to, Immunodepletion, Immunocompetition.
Confocal Microscopy: 1:250
Western Blot: 1:500-1:1,000. Researchers should empirically determine the suitability of the PDE5A pde5a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PDE5A pde5a product has the following accession number(s) (GI #317373261) (NCBI Accession #O76074.2) (Uniprot Accession #O76074). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Antigenic Blocking Peptide cGMP-specific 3\', 5\'-cyclic phosphodiesterase isoform 1
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5\'-GMP.
Immunogen: Synthetic peptide common to all PDE5A variants taken within amino acid region 120-170 on human PDE5A protein.
Expression: Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. Molecular Function: Hydrolase, 3\', 5\'-cyclic-GMP phosphodiesterase activity, cGMP binding
Subcellular Location: Cytosol. PDE5A also interacts with the following gene(s): ADCY3, ADCY7, PRKG1. The following patways have been known to be associated with this gene. Cardiomegaly, Cardiovascular Diseases, Disease Models, Animal, Erectile Dysfunction, Fibrosis, Heart Diseases, Hypertension, Hypertrophy, Lung Diseases, Nervous System Diseases are some of the diseases may be linked to PDE5A Peptide. Brain, Eye, Heart, Kidney, Lung, Muscle, Nerve, Prostate, Testis, Vascular tissues are correlated with this protein.