|The PAX6 pax6 (Catalog #MBS9226434) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The PAX6 pax6 product has the following accession number(s) (GI #6174889) (NCBI Accession #P26367.2) (Uniprot Accession #P26367). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Cellular Location: Nucleus. Tissue Location: Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form. Aniridia, Brain Diseases, Coloboma, Craniofacial Abnormalities, Diabetes Mellitus, Experimental, Intellectual Disability, Kidney Diseases, Necrosis, Nervous System Malformations, Peters anomaly are some of the diseases may be linked to PAX6 Antibody (Center) Blocking Peptide. PAX6 also interacts with the following gene(s): BMP4, FOXA2, GCG, INS, NEUROD1, NKX2-2, SIX3, SIX6, SOX2. The following patways have been known to be associated with this gene. Bone, Brain, Embryonic Tissue, Eye, Kidney, Lung, Mouth, Muscle, Pancreas, Skin tissues are correlated with this protein.