PARD3 blocking peptide product blog
Tags: Blocking Peptide; PARD3; PARD3 blocking peptide;
The PARD3 pard3 (Catalog #MBS9227783) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The PARD3 pard3 product has the following accession number(s) (GI #30913162) (NCBI Accession #Q8TEW0.2) (Uniprot Accession #Q8TEW0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.
Cellular Location: Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cell membrane. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note: Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II Colocalized with SIRT2 in internode region of myelin sheat (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. Tissue Location: Widely expressed. PARD3 also interacts with the following gene(s): JAM3, PARD6A, PARD6B, PRKCI, PRKCZ, TIAM1. Blood, Brain, Eye, Kidney, Liver, Mammary Gland, Muscle, Nerve, Skin, Vascular tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Congenital Abnormalities, Inflammation, Kidney Diseases, Liver Neoplasms, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to PARD3 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene.