PAPP-A recombinant protein product blog
Tags: Recombinant Protein; PAPP-A recombinant protein; PAPP-A; Pregnancy-Associated Plasma Protein-1 (Western Blot Control);
The PAPP-1A n/a (Catalog #MBS343113) is a Western Blot Control and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
PAPP-An is a large zinc binding protein, which acts as a metalloprotease and has been shown to cleave insulin-like growth factor binding protein-4. PAPP-A can act as a regulator of IGF bioactivity in several biological systems, including the human ovary and cardiovascular systems. Recent studies have shown that levels are elevated in patients with unstable angina or acute myocardial infarction. PAPP-An is also produced in high concentrations during pregnancy and is released into the maternal circulation. Low levels of PAPP-A have been linked with a number of foetal chromosomal abnormalities, as well as pre-eclampsia and stillbirth. Recombinant PAPP-A comprises a 191 amino acid fragment (81-271) corresponding to the PAPP-A Jelly-Roll domain fragment and is expressed in E Coli with an aminoterminal hexahistidine tag. This product is not intended for therapeutic use.
Buffer: Buffered 50% glycerol.