PALB2 blocking peptide product blog
Tags: PALB2; Blocking Peptide; PALB2 blocking peptide;
The PALB2 palb2 (Catalog #MBS9218564) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The PALB2 palb2 product has the following accession number(s) (GI #74727919) (NCBI Accession #Q86YC2.1) (Uniprot Accession #Q86YC2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity.
Cellular Location: Nucleus. Note: Colocalizes with BRCA2 in nuclear foci. Bladder, Bone, Brain, Intestine, Kidney, Lung, Lymph Node, Mammary Gland, Pancreas, Skin tissues are correlated with this protein. Adenocarcinoma, Anemia, Ataxia, Breast Neoplasms, Carcinoma, Chromosome Breakage, Fanconi Anemia, Complementation Group N, Genital Diseases, Female, Neoplasms, Experimental, Pancreatic Neoplasms are some of the diseases may be linked to PALB2 Antibody (Center) Blocking peptide. The following patways have been known to be associated with this gene.