Pak7 blocking peptide product blog
Tags: Blocking Peptide; PAK7; PAK7 blocking peptide;
The Pak7 pak7 (Catalog #MBS9220438) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Pak7 pak7 product has the following accession number(s) (GI #76363285) (NCBI Accession #Q8C015.1) (Uniprot Accession #Q8C015). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity).
Cellular Location: Mitochondrion. Cytoplasm. Nucleus. Note: Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival. Tissue Location: Highly expressed in brain and eye. Also expressed in adrenal gland, pancreas, prostate and testes. Within the brain, expression is restricted to neurons. Present in brain but not in kidney, lung and spleen (at protein level). Adenocarcinoma, Anemia, Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Liver Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms are some of the diseases may be linked to Mouse Pak7 Antibody (N-term) Blocking peptide. Brain, Embryonic Tissue, Eye, Ovary, Spinal Cord, Testis tissues are correlated with this protein. Pak7 also interacts with the following gene(s): Cdc42, Rac1. The following patways have been known to be associated with this gene.