Pak3 blocking peptide product blog
Tags: Blocking Peptide; PAK3; PAK3 blocking peptide;
The Pak3 pak3 (Catalog #MBS9220309) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Pak3 pak3 product has the following accession number(s) (GI #47117898) (NCBI Accession #Q61036.2) (Uniprot Accession #Q61036). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Key regulator of synapse formation and plasticity in the hippocampus.
Cellular Location: Cytoplasm. Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. Pak3 also interacts with the following gene(s): Arhgef6, Arhgef7, Cdc42, Nck1, Nck2, Rac1, Raf1. Adrenal Gland, Brain, Dorsal Root Ganglion, Embryonic Tissue, Eye, Pancreas, Pituitary Gland, Prostate, Spinal Cord, Testis tissues are correlated with this protein. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Cognition Disorders, Congenital Abnormalities, Disease Models, Animal, Kidney Diseases, Learning Disorders, Lung Diseases, Memory Disorders, Uterine Cervical Neoplasms are some of the diseases may be linked to Mouse Pak3 Antibody (N-term) Blocking peptide.