p27 KIP1 positive control product blog
Tags: p27 Kip1; Positive Control; p27 KIP1 positive control; Phospho-p27 KIP1;
The p27 KIP1 n/a (Catalog #MBS543134) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Phospho-p27 KIP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western Blot: 1:250. Researchers should empirically determine the suitability of the p27 KIP1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The p27 KIP1 n/a product has the following accession number(s) (GI #12805035) (NCBI Accession #AAH01971.1) (Uniprot Accession #Q9NYG6). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Western Blot Positive Control Phosphorylated Cyclin-dependent kinase inhibitor p27kip1 Antibody C-epitope
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Immunogen: Purified Protein
Expression: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney. Determinant: C-epitope
Molecular Function: Cyclin-dependent protein serine/threonine kinase inhibitor activity, kinase activity
Structure: Forms a ternary complex with CCNE1/CDK2/CDKN1B. Interacts directly with CCNE1; the interaction is inhibited by CDK2-dependent phosphorylation on Thr-187. Interacts with COPS5, subunit of the COP9 signalosome complex; the interaction leads to CDKN1B degrad
Subcellular Location: Nucleus. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Kidney, Liver, Lung, Lymph Node, Muscle, Prostate, Vascular tissues are correlated with this protein. p27 KIP1 also interacts with the following gene(s): AKT1, CCNA2, CCND1, CCND3, CCNE1, CDK2, CDK4, CDK6, SKP2, UBC.