OX40 recombinant protein product blog
Tags: Recombinant Protein; OX40; OX40 recombinant protein;
The OX40 tnfsf4 (Catalog #MBS539580) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s OX40 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the OX40 tnfsf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The OX40 tnfsf4 product has the following accession number(s) (GI #11275538) (NCBI Accession #BAB18304.1) (Uniprot Accession #P23510). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including OX40 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL2, IL3, and IFN.
Bioactivity: Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/ml. Note: Results may vary with PBMC donors.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System: Hi-5 cells. Bone Marrow, Brain, Eye, Larynx, Liver, Lung, Lymph Node, Mixed, Skin, Thymus tissues are correlated with this protein. Cardiovascular Diseases, Fibrosis, Heart Diseases, Inflammation, Kidney Diseases, Lung Diseases, Lupus Erythematosus, Systemic, Myocardial Infarction, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to OX40 Ligand protein. The following patways have been known to be associated with this gene. OX40 also interacts with the following gene(s): ATM, CD8A, FOS, FOXP3, HDAC11, OLR1, TNFRSF4, TNFSF15, TNFSF8, TNFSF9.