OTULIN blocking peptide product blog
Tags: Blocking Peptide; FAM105B; OTULIN; OTULIN blocking peptide;
The OTULIN otulin (Catalog #MBS9225760) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The OTULIN otulin product has the following accession number(s) (GI #115334675) (NCBI Accession #NP_612357.4) (Uniprot Accession #Q96BN8). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Deubiquitinase that specifically removes linear (\'Met- 1\'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.
Cellular Location: Cytoplasm. Dermatitis, Inflammation, Necrosis are some of the diseases may be linked to FAM105B Antibody (Center) Blocking peptide. The following patways have been known to be associated with this gene.