OTUB1 blocking peptide product blog
Tags: OTUB1; Blocking Peptide; OTUB1 blocking peptide;
The OTUB1 otub1 (Catalog #MBS9230160) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The OTUB1 otub1 product has the following accession number(s) (GI #44888286) (NCBI Accession #Q96FW1.2) (Uniprot Accession #Q96FW1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Hydrolase that can specifically remove \'Lys-48\'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of \'Lys- 48\'-linked polyubiquitin chains, but not \'Lys-63\'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to \'Lys-48\'-linked ubiquitin.
Cellular Location: Cytoplasm. Tissue Location: Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells. OTUB1 also interacts with the following gene(s): NMRAL1, TRAF3, UBC, UBE2D2, UBE2N, UBE2V2. Adenocarcinoma, Death, Disease Models, Animal, Fibrosis, Inflammation, Kidney Diseases, Necrosis are some of the diseases may be linked to OTUB1 Blocking Peptide (C-Term). Blood, Bone Marrow, Kidney, Liver, Lung, Lymph, Lymph Node, Ovary, Prostate, Spleen tissues are correlated with this protein.