|The NT3 ntf3 (Catalog #MBS538197) is a Recombinant Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s NT3 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the NT3 ntf3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NT3 ntf3 product has the following accession number(s) (GI #4505469) (NCBI Accession #NP_002518.1) (Uniprot Accession #P20783). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Region of NT3 protein correspond ing to amino acids MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including NT3 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: NT-3 is a neurotrophic factor structurally related to beta-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, Mouse and rat NT-3 are identical.
Bioactivity: The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System: E Coli. Brain, Embryonic Tissue, Eye, Ovary, Testis tissues are correlated with this protein. Cognition Disorders, Disease Models, Animal, Hearing Loss, Hypertension, Inflammation, Learning Disorders, Memory Disorders, Neoplasm Metastasis, Nervous System Diseases, Schizophrenia are some of the diseases may be linked to NT3 protein. The following patways have been known to be associated with this gene. NT3 also interacts with the following gene(s): BDNF, CREB1, NGFR, NTRK1, NTRK2, NTRK3.