NRP1 blocking peptide product blog
Tags: Blocking Peptide; NRP1; NRP1 blocking peptide;
The NRP1 nrp1 (Catalog #MBS9227998) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The NRP1 nrp1 product has the following accession number(s) (GI #206729912) (NCBI Accession #O14786.3) (Uniprot Accession #O14786). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Blood, Bone, Brain, Embryonic Tissue, Heart, Lung, Lymph Node, Muscle, Nerve, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Inflammation, Liver Neoplasms, Neoplasms, Experimental, Nervous System Diseases, Prostatic Neoplasms are some of the diseases may be linked to NRP1 Antibody (C-term) Blocking Peptide. NRP1 also interacts with the following gene(s): CHL1, FLT1, KDR, PGF, PLXNA1, PLXNA2, PLXNA4, SEMA3A, SEMA3C, VEGFA.