NPC1 blocking peptide product blog
Tags: NPC1; Blocking Peptide; NPC1 blocking peptide;
The NPC1 npc1 (Catalog #MBS9219932) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The NPC1 npc1 product has the following accession number(s) (GI #83305902) (NCBI Accession #O15118.2) (Uniprot Accession #O15118). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular \'tag team duo\' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals.
Cellular Location: Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. The following patways have been known to be associated with this gene. NPC1 also interacts with the following gene(s): ABCA1, ABCG1, ANXA6, CTSD, LRP6, NPC2, TMEM97, UBC. Blood, Bone, Bone Marrow, Brain, Liver, Lung, Ovary, Skin, Spleen, Vascular tissues are correlated with this protein. Ataxia, Atherosclerosis, Disease Models, Animal, Dysarthria, Inflammation, Liver Diseases, Nerve Degeneration, Niemann-Pick Disease, Type C, Obesity, Weight Loss are some of the diseases may be linked to NPC1 Antibody (Center) Blocking peptide.