|The NOTCH1 notch1 (Catalog #MBS9229719) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The NOTCH1 notch1 product has the following accession number(s) (GI #206729936) (NCBI Accession #P46531.4) (Uniprot Accession #P46531). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. Blood, Bone, Bone Marrow, Brain, Embryonic Tissue, Heart, Liver, Lung, Muscle, Vascular tissues are correlated with this protein. NOTCH1 also interacts with the following gene(s): ADAM17, DTX1, FBXW7, HEY1, HEY2, MAML1, NUMB, PSEN1, RBPJ, UBC. Breast Neoplasms, Cell Transformation, Neoplastic, Congenital Abnormalities, Heart Diseases, Inflammation, Leukemia, T-Cell, Liver Diseases, Lymphoma, Nervous System Diseases, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma are some of the diseases may be linked to NOTCH1 Blocking Peptide (C-term). The following patways have been known to be associated with this gene.