Non-CpG DNA, Rabbit, BioGenomics dna product blog
Tags: DNA; Non-CpG DNA, Rabbit, BioGenomics; Non-CpG DNA, Rabbit, BioGenomics dna;
The Non-CpG DNA, Rabbit, BioGenomics n/a (Catalog #MBS653511) is a DNA Ladder and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Non-CpG DNA, Rabbit, BioGenomics can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA).Suitable for use in ELISA. Researchers should empirically determine the suitability of the Non-CpG DNA, Rabbit, BioGenomics n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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ODN 2041 is a prototype of non-CpG oligodeoxynucleotides (ODN) that is not able to stimulate rabbit PBMC in vitro. The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect unmethylated cytosine-phosphate-guanine (CpG) motifs within bacterial DNA. Cellular activation by CpG motifs occurs via the Toll signal pathway. The Toll-like receptor-9 (TLR9, CD289) appears to be a major component of the CpG-DNA receptor, acting by direct binding to CpG-DNA, which triggers the induction of cell signaling pathways including the mitogen activated protein kinase (MAPKs) and NFkB, leading to stimulation of various cells of the immune system. The human TLR9 is expressed in B cells and plasmacytoid dendritic cells (PDC). Mice also express TLR9 in the myeloid compartment. Optimal sequences for activating TLR9 vary among species. Synthetic ODN contain CpG-DNA motifs mimicking the immunostimulatory effects of bacterial DNA and can, therefore, be used as immunoprotective agents, vaccine adjuvants and anti-allergic agents. CpG ODN also affects.