NME1 blocking peptide product blog
Tags: NME1; Blocking Peptide; NME1 blocking peptide;
The NME1 nme1 (Catalog #MBS9221247) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The NME1 nme1 product has the following accession number(s) (GI #127981) (NCBI Accession #P15531.1) (Uniprot Accession #P15531). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3\'-5\' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3\' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Cellular Location: Cytoplasm. Nucleus. Note: Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. Tissue Location: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. Adenocarcinoma, Breast Neoplasms, Carcinoma, Carcinoma, Squamous Cell, Colorectal Neoplasms, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasm Invasiveness, Neoplasm Metastasis are some of the diseases may be linked to NME1 Antibody (C-term) Blocking Peptide. Blood, Bone, Brain, Liver, Lung, Lymph, Lymph Node, Skin, Stomach, Vascular tissues are correlated with this protein. NME1 also interacts with the following gene(s): APEX1, CDC42, RAC1, SET, TIAM1. The following patways have been known to be associated with this gene.