Necrostatin small molecule product blog
Tags: Small Molecule; Necrostatin; Necrostatin small molecule;
The Necrostatin n/a (Catalog #MBS807958) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given small molecule. We\'ve tested the Necrostatin with the following immunoassay(s):
Chemical Structure (Chemical structure of Necrostatin (SIH-213), an Inhibits necroptosis. CAS #: 4311-88-0. Molecular Formula: C13H13N3OS. Molecular Weight: 259.33 g/mol.)
Necrostatin-1 is a specific inhibitor of necroptosis that reduces ischemic tissue damage in stroke models (1). It has also been recently confirmed to be an allosteric RIP1 kinase inhibitor, preotective in NMDa-mediated excitotoxicity and acute pathologies (2,3).
Solubility: Soluble to 15 mM in ethanol, and to 30 mM in DMSO
CAS Number: 4311-88-0
Molecular Formula: C13H13N3OS
SMILES: CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
InChI: 1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChI Key: TXUWMXQFNYDOEZ-UHFFFAOYSA-N
PubChem CID: 2828334
PubMed ID: 29152118; 27592300; 25341043.