|The NCK1 nck1 (Catalog #MBS9220140) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The NCK1 nck1 product has the following accession number(s) (GI #127962) (NCBI Accession #P16333.1) (Uniprot Accession #P16333). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
Cellular Location: Cytoplasm. Endoplasmic reticulum. Nucleus. Note: Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments. NCK1 also interacts with the following gene(s): CBL, EGFR, PAK1, PDGFRB, WASL. Atrophy, Carcinoma, Hepatocellular, Fever, Kidney Diseases, Liver Diseases, Lung Neoplasms, Neoplasm Metastasis, Nervous System Diseases, Pain, Proteinuria are some of the diseases may be linked to NCK1 Antibody (N-term) Blocking peptide. Eye, Lung, Pancreas tissues are correlated with this protein. The following patways have been known to be associated with this gene.