Myelin Basic Protein [des-Gly77, des-His78] peptide product blog
Tags: Peptide; Myelin Basic Protein [des-Gly77, des-His78]; Myelin Basic Protein [des-Gly77, des-His78] peptide;
The Myelin Basic Protein [des-Gly77, des-His78] n/a (Catalog #MBS659299) is a Peptide produced from Synthetic peptide and is intended for research purposes only. The product is available for immediate purchase. The Myelin Basic Protein [des-Gly77, des-His78] (68-84) (guinea pig) reacts with Guinea Pig and may cross-react with other species as described in the data sheet.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
In vitro, myelin basic protein (MBP) is a substrate for phosphorylation by several different protein kinases including MAPK, PKA, calmodulin-dependent protein kinase, PKC and phosphorylase kinase. Even highly specific protein kinases such as Raf1, MEK and MEKK can utilize MBP as an alternative substrate. Myelin basic protein (MBP) is a single-chain, flexible polypeptide of about 18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized in the compact myelin sheath. MBP has not been demonstrated in rough endoplasmic reticulum, lysosomes or any other cytoplasmic organelles. MBP serves as a marker for oligodendrocytes and Schwann cells. MBP is also a marker for malignant schwannomas and appears to play a significant role in the etiology of multiple sclerosis and experimental autoimmune encephalomyelitis.
Sequence (linear): Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn
Molecular Formula: C71H113N23O28.