|The MYD88 myd88 (Catalog #MBS9227680) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The MYD88 myd88 product has the following accession number(s) (GI #18202671) (NCBI Accession #Q99836.1) (Uniprot Accession #Q99836). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Cellular Location: Cytoplasm. Tissue Location: Ubiquitous.. MYD88 also interacts with the following gene(s): IL1R1, IRAK2, IRAK3, IRAK4, TIRAP, TLR3, TLR4, TLR5, TRAF6. Blood, Bone, Bone Marrow, Brain, Intestine, Kidney, Liver, Lung, Spleen, Vascular tissues are correlated with this protein. Cardiovascular Diseases, Disease Models, Animal, Fibrosis, Inflammation, Kidney Diseases, Liver Diseases, Lung Diseases, MYD88 Deficiency, Necrosis, Pneumonia are some of the diseases may be linked to MyD88 Antibody (Center) Blocking Peptide. The following patways have been known to be associated with this gene.