|The Mubritinib n/a (Catalog #MBS8506551) is a Kinase Inhibitor and is intended for research purposes only. The product is available for immediate purchase.
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Please refer to the product datasheet for known applications of a given kinase inhibitor. We\'ve tested the Mubritinib (TAK 165) with the following immunoassay(s):
Mubritinib(TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 uM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5. Mubritinib(TAK 165) displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Mubritinib(TAK 165) exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo. .
Solubility: Unknown. Formula: C25H23F3N4O2
CAS Number: 366017-09-6.