MST1R blocking peptide product blog
Tags: MST1R; Blocking Peptide; RON; MST1R blocking peptide;
The MST1R mst1r (Catalog #MBS9227154) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MST1R mst1r product has the following accession number(s) (GI #294862462) (NCBI Accession #Q04912.2) (Uniprot Accession #Q04912). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Cellular Location: Membrane; Single-pass type I membrane protein. Tissue Location: Expressed in colon, skin, lung and bone marrow. Bladder, Lung, Mammary Gland, Prostate, Stomach tissues are correlated with this protein. The following patways have been known to be associated with this gene.