MRC2 blocking peptide product blog
Tags: Blocking Peptide; MRC2; MRC2 blocking peptide;
The MRC2 mrc2 (Catalog #MBS9221403) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MRC2 mrc2 product has the following accession number(s) (GI #317373394) (NCBI Accession #Q9UBG0.2) (Uniprot Accession #Q9UBG0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Cellular Location: Membrane; Single-pass type I membrane protein. Tissue Location: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon Expressed in endothelial cells, fibroblasts and macrophages Highly expressed in fetal lung and kidney. MRC2 also interacts with the following gene(s): PLAUR. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Disease Models, Animal, Fibrosis, Inflammation, Kidney Diseases, Liver Diseases, Lung Diseases, Neoplasm Metastasis, Nervous System Diseases are some of the diseases may be linked to MRC2 Antibody (Center) Blocking Peptide. Blood, Bone, Connective Tissue, Kidney, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein.